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CHARACTERIZATION, BEHAVIOR AND PLASTICITY OF PLURIPOTENT STEM CELLS

Published on AidPage by IDILOGIC on Jun 24, 2005
Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:
  • Original Grant - May 10, 2004
Applications Due:


Multiple Receipt Dates - See Link to Full Announcement for details.

total funding: Not Available
max award: $137,500
min award: none
cost sharing, matching: No
number of awards: Not Available
type of funding: Grant
Description:

Stem cells appear to possess great plasticity, but the cellular mechanisms
regulating their behavior and fate are not understood. If these mechanisms
can be harnessed to obtain cells specifically required for therapy, diagnosis
or drug discovery, it may be possible to restore function to tissues and
organ systems that have been compromised by congenital disorders,
developmental malfunction, age, injury, disease or drug exposure. The
National Institute of Neurological Disorders and Stroke (NINDS), the National
Institute on Deafness and Other Communication Disorders (NIDCD), the National
Institute on Aging (NIA), the National Institute of Child Health and Human
Development (NICHD), the National Cancer Institute (NCI), the National
Institute of Drug Abuse (NIDA), and the National Institute of Mental Health
(NIMH) invite applications for studies on the characterization, behavior and
plasticity of human and non-human stem cells, regulation of their
replication, differentiation, integration and function in the nervous system,
and the identification and characterization of normal and tumor stem cells.
An understanding of intrinsic and extrinsic signals, especially those
involved in the stem cell niche, age-dependent processes and genetic factors
that govern the activities of pluripotent cells is crucial in order to
utilize them to develop safe and effective treatments for the restoration of
function, or to prevent their transformation into tumor-generating cells.
Although animal studies demonstrate that stem or progenitor cells can be
derived from a variety of tissues and from hosts of different ages, the
requirements and potential for differentiation of each type of pluripotent
cell appear to be unique. We lack a clear understanding of the intrinsic
properties that distinguish one population from another, and how these
populations differ in their response to similar conditions in vitro and in
vivo. This Program Announcement, which replaces PA-01-078 (Biology of Non-
Human Stem Cells in the Environment of the Nervous System) and PA-02-025
(Plasticity of Human Stem Cells in the Nervous System), encourages
applications to study the fundamental properties of all classes of human and
non-human stem cells, and to confirm, extend, and compare the behavior of
stem cells that are derived from different sources and ages or exposed to
different regimes in vitro and in vivo or derived from tumors. Of high
priority are studies to develop methods for identifying, isolating and
characterizing specific precursor populations at intermediate stages of
differentiation into neurons and glia, and their relationship to tumor-
generating cells. Projects that address comparisons between different classes
of human stem cells and between human and non-human stem cells would also be
directly relevant to this PA.

Who can apply:

Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Individual/Family
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)

Eligible functional categories:
Funding Sources:

Aging Research
Cancer Biology Research
Center for Medical Rehabilitation Research
Drug Abuse Research Programs
Extramural Research Programs in the Neurosciences and Neurological Disorders
Mental Health Research Grants
Research Related to Deafness and Communication Disorders

More Information:

http://grants.nih.gov/grants/guide/pa-files/PA-04-101.html

If you have problems accessing the full announcement, please contact: NIH OER Webmaster

Address Info:

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